Duratia 60 mg contains Tadalafil, a phosphodiesterase type 5 (PDE5) inhibitor used for erectile dysfunction (ED). Headaches are one of the common side effects of this medication. People who may experience headaches from Duratia 60 mg include: Men taking the medication for the first time – some may be more sensitive to the effects on blood vessels. Individuals with a history of migraines or frequent headaches – they may be more prone to experiencing headaches as a side effect. Those taking higher doses or exceeding the recommended dose – excessive Tadalafil can increase the risk of headaches. People who consume alcohol or fatty meals with the medication – this may increase side effects like headaches or dizziness. Individuals with cardiovascular conditions – changes in blood flow or blood pressure may trigger headaches. Usually, these headaches are mild to moderate and temporary. Drinking water, resting, or taking mild pain relievers (with doctor approval) often helps. If a headache is severe, persistent, or accompanied by vision changes or chest pain, medical attention should be sought immediately. I can also explain why Tadalafil specifically causes headaches if you want a more scientific breakdown.