Tadalista 60 mg is a high-strength tadalafil tablet for erectile dysfunction (ED), so there are several important warnings and precautions you should be aware of before using it. Because this is a 60 mg dose — higher than standard 10–20 mg — the risks can be greater.  Major Warnings for Tadalista 60 mg Heart-Related Risks Do not take if you have severe heart problems, like recent heart attack, unstable angina, or severe heart failure. ***** activity itself increases heart strain, so consult your doctor first. Can interact dangerously with nitrates (medications for chest pain), causing a dangerous drop in blood pressure. Blood Pressure Risks Tadalafil can lower blood pressure, especially when combined with nitrates, alpha-blockers (used for prostate issues), or certain blood pressure medicines. Dizziness, fainting, or sudden vision problems may occur. Priapism (Prolonged Erection) If an erection lasts more than 4 hours, seek urgent medical attention — untreated priapism can cause permanent damage to the *****. Vision and Hearing Changes Rarely, tadalafil can cause sudden vision loss (NAION) or hearing loss. Stop using immediately and seek medical attention if these occur. Kidney or Liver Problems High doses may increase strain on kidneys or liver, especially if you already have disease. Dose adjustment or monitoring may be required. Drug Interactions Avoid other ED drugs, nitrates, or certain antifungals, antibiotics, and HIV medications without doctor approval. Alcohol or grapefruit may worsen side effects like dizziness or headache. Other Precautions Not for use in women or children. Use with caution if you have conditions like sickle cell anemia, multiple myeloma, or leukemia, which increase the risk of priapism.