Vilitra 40 (vardenafil 40 mg) are usually temporary and fade as the drug leaves your system.  Typical timeline Mild side effects (headache, flushing, nasal congestion, dizziness): Usually disappear within 4 to 8 hours, often as the main effect of the medicine wears off. Digestive upset (indigestion, nausea): May last a few hours up to ~12 hours in some people. Muscle/back pain (less common): Can occasionally last 12 to 24 hours, but usually improves on its own.  Why this happens Vardenafil stays active in the body for about 4–6 hours (sometimes slightly longer). As its concentration drops, blood vessels and body systems return to normal, and side effects resolve. When to be concerned Seek medical help if you have: Chest pain or fainting Severe dizziness that doesn’t improve Vision or hearing changes Erection lasting more than 4 hours (priapism)  Key point For most people, side effects from Vilitra 40 are short-lived (same day) and fade as the drug clears from the bloodstream. If you tell me what side effect you’re experiencing, I can give a more precise estimate for that specific symptom.