Suhagra 50 mg (sildenafil) should not be mixed with nitrates because the combination can cause a dangerous drop in blood pressure. People who should avoid this combination include those taking: Nitrate medicines for chest pain (angina), such as: Nitroglycerin (glyceryl trinitrate/GTN) tablets, sprays, or patches Isosorbide mononitrate Isosorbide dinitrate Recreational “poppers” that contain nitrate-like substances (such as amyl nitrite) This warning is especially important for people with: Heart disease requiring nitrate treatment A history of angina or chest pain treated with nitrates Certain cardiovascular conditions where blood pressure is already low or unstable If someone has taken Suhagra and then develops chest pain, they should tell emergency medical staff that they have taken sildenafil and not take nitrates unless directed by a medical professional. If you tell me the name of any heart or blood pressure medicines you take, I can help check whether there may be an interaction.